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Scientists at the University of Guelph have found a way to successfully clone American elm trees that have survived repeated epidemics of their biggest killer ? Dutch elm disease.
The breakthrough, published today in the Canadian Journal of Forest Research, is the first known use of in vitro culture technology to clone buds of mature American elm trees.
"This research has the potential to bring back the beloved American elm population to North America," said Prof. Praveen Saxena, a plant scientist who worked on the project with Professor Alan Sullivan. Both are from Guelph's Department of Plant Agriculture.
"It may also serve as a model to help propagate and preserve thousands of other endangered plant species at risk of extinction across the globe."
Majestic American elms were among the most popular and recognizable trees in Ontario, lining boulevards and adorning city centres. But more than 95 per cent of the population in Eastern Canada and the United States has now been wiped out by Dutch elm disease.
The imported fungal infection interferes with water transport and stops nutrients from circulating in the tree. Only about one in 100,000 elms may be naturally resistant to the pathogen.
Looking for new techniques to clone and produce resistant trees through micropropagation, the Guelph researchers selected tissue samples from survivors in Ontario, including a century-old elm tree growing on the U of G campus.
"The trees that have survived initial and subsequent epidemics potentially represent an invaluable source of potential disease resistance for future plantings and breeding programs," Saxena said.
After growing genetic copies from the shoot tips and dormant buds, the researchers hope to select germplasm with the desired traits including disease-resistance which will further aid elm breeding and biotechnology programs around the world.
They also perfected a way to conserve germplasm over the long term. A germplasm repository now contains 17 accessions collected from mature elm trees that survived across Ontario.
"Our results demonstrate the usefulness of in vitro technologies for conserving and reintroducing endangered germplasm of economic, social and environment significance," Saxena said.
In vitro conservation technology is highly efficient and better than seed banks for conservation of many plant species, he added. Hundreds of genotypes with known phenotypes can be conserved in a safe small space and can easily be propagated.
The professors worked with Guelph postdoctoral researchers Mukund Shukla and Maxwell Jones; Chunzhao Liu, Professor, Chinese Academy of Sciences in Beijing; and Susan Gosling of the Gosling Foundation.
"We want to conserve and propagate the American elm and many other rare and endangered Canadian native species so that we can start to replace what has been decimated along the way," said Gosling.
Saxena said the team hopes to reintroduce disease-resistant trees. "The need to conserve endangered plant species in provinces such as Ontario where urban sprawl continues is crucial and urgent."
###
University of Guelph: http://www.uoguelph.ca
Thanks to University of Guelph for this article.
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When a particular person files for bankruptcy (Chapter 7, 13, or eleven), all her or his creditors are immediately prevented from making an attempt to collect the personal debt. This is certainly identified as the ?automatic continue to be.? What this means is that filing for a bankruptcy instantly relieves anyone from creditor harassment this sort of as irritating phone calls, lawsuits, repossessions, foreclosures, and every other system for selection of a financial debt.
Likewise, just before Bankruptcy, a creditor may possibly initiate the wage garnishment technique versus you in order to acquire 25% of one?s wages. The submitting of the Chapter 7 Bankruptcy instantly stops the creditor from proceeding together with the wage garnishment. Inside the exact same way, your finance company may be stopped right away from repossessing your car. They are all examples with the ?automatic stay? of Bankruptcy.
Chapter 7 is sometimes named a ?liquidation? or ?straight? bankruptcy. In Chapter 7, a business or buyer debtor obtains a ?discharge? of all debts following a Bankruptcy Trustee [appointed through the court] possibly liquidates the debtor?s assets to spend creditors or decides which the debtor has no assets to spend lenders. A discharge is definitely an order in the Bankruptcy court stating which the debtor is released from debt, this kind of to be a credit card statement. Quite simply, the credit card debt is wiped out and the debtor no more owes the creditor any dollars.
In most purchaser instances, there are no assets for that Trustee to research or administer. It is because most buyers have assets that may be exempted beneath California regulation. By way of example, less than California legislation you could exempt your home furniture, jewellery, garments, etcetera.
It?s possible you?ll retain your car in Chapter 7 Bankruptcy for those who want to do so and you also are current on the regular finance payments. Then again, it?s possible you?ll also surrender your car in the event you would like and you also will discharge all liability to the finance company.
The new bankruptcy regulation imposes the new need which you will have to now acquire a briefing from an approved nonprofit credit score counseling agency within 180 times of one?s bankruptcy submitting. Underneath the newest bankruptcy legislation, you won?t be eligible to file a Chapter 7 Bankruptcy if the profits is earlier mentioned the median cash flow on the condition in which you are living, and you can pay for to shell out a particular volume of your debts. On top of that, a Chapter 7 debtor?s discharge will probably be denied if your debtor acquired a Chapter 13 Bankruptcy eleven discharge in the former circumstance submitted within 8 several years of your present-day situation.
A Chapter 7 won?t enable you to make a plan of repayment on your collectors. For anyone who is driving with your home loan and need to ?cure? or make up payments to your home loan company, you need to file a Chapter 13 Bankruptcy.
Want to find out more concerning How to file bankruptcy, then go to Rockisto Moresa?s site on how to choose the perfect Bankruptcy Attorney for your needs.
For as long as we've known about definite plans for the two planned "Avatar" sequels, James Cameron has talked openly about his ambition to explore the oceans of Pandora. Back on Earth, Cameron has been busy exploring the oceans we all know in his solo trips to the very bottom. When MTV UK spoke with [...]
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ST LOUIS, MO - MARCH 25: Thomas Robinson #0 of the Kansas Jayhawks dunks against Reggie Bullock #35 of North Carolina Tar Heels.
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SHANGHAI?China is considering the launch of a new equity exchange to help the country's smaller companies raise funds, according to two people familiar with the situation, as the government looks for ways to boost liquidity for such firms.
The new exchange, likely to be in Beijing, will be what's known as an equity exchange, the people said. Unlike a stock exchange, it won't be a venue for initial public offerings.
It will allow investors to trade shares in ...
SHANGHAI?China is considering the launch of a new equity exchange to help the country's smaller companies raise funds, according to two people familiar with the situation, as the government looks for ways to boost liquidity for such firms.
The new exchange, likely to be in Beijing, will be what's known as an equity exchange, the people said. Unlike a stock exchange, it won't be a venue for initial public offerings.
Jennifer Lopez has dismissed reports she?s secretly wed her toyboy lover Casper Smart. The superstar found a photo of herself on the cover of this week?s Star magazine alongside the headline, ?J.Lo Married in Mexico!?.
The accompanying article alleges the singer/actress married dancer Smart in a low-key ceremony onboard a yacht ? with no guests in attendance. The story also suggested Lopez had signed a prenuptial agreement promising her new husband $1 million a year for the next decade.
But Lopez ? who split from her third husband, salsa singer Marc Anthony, last summer- has brushed off the new tabloid claims.
In a Twitter.com post on Thursday, she writes, ?I keep seeing something about getting married. Surprise, surprise ?they? are wrong?AGAIN. #boredtweet?.
It?s the second time Lopez has had to deny rumors she?s heading down the aisle again ? last week, she shut down false allegations claiming she had asked fashion designer Roberto Cavalli to create a new wedding dress, insisting the style guru?s Twitter.com page had been hacked.
The Epson LabelWorks LW-400 Label Printer ($49.99 direct) is the slightly higher priced of the two standalone label printers that Epson recently released, and it offers a few extra features (such as barcode printing) than the Epson LabelWorks LW-300 ($39.99 direct, 3.5 stars). It lets you print labels without a PC on plastic and similar tapes offered by Epson and can print anywhere, anytime, though with its cramped keyboard you may miss the comfort of composing labels on a computer.
The matte-black LW-400 measures 6.7 by 4.3 by 2.2 inches and weighs 1.2 pounds. I had no trouble holding it in one hand. It?s nearly an inch slimmer than the LW-300. Its svelteness has a downside in that the LW-400?s QWERTY keyboard is correspondingly narrower and harder to type with. As it?s a standalone label printer, you don?t have the option of using a computer keyboard. The Editors? Choice Brother P-touch PT-2730 ($100 street, 4 stars) operates either standalone or connected to a computer, as does the Dymo LabelManager 420P ($110 street, 4 stars), though the Dymo?s own keyboard is arranged alphabetically rather than QWERTY.
Its advantages over the Epson LW-300 include a backlit display; the ability to store 50 user-created label designs in memory (to the Epson LW-300?s 30); wider labels (3/4 inches to the LW-300?s half-inch); and the ability to print barcodes, double-sided label tabs, and flag or wrapped labels for cabling. (Supported barcode formats include CODE39, CODE128, ITF, CODABAR, UPC-A, UPC-E, EAN-8, and EAN-13.)
Epson offers 41 different label cartridges up to 3/4 inch wide for the LW-400, including standard, strong adhesive, clear, fluorescent glow-in-the-dark, iron-on (fabric), folder tab, metallic, and pearlized, in several different text and background color combinations.
The LW-400 is powered by 6 AA batteries. Should you forget to turn it off, it will shut itself off after 5 minutes. The printer?s bottom snaps open so you can replace batteries or the tape cartridge. An optional AC adapter is available for $25 (direct).
Inserting a label cartridge is literally a snap. Once you remove the printer?s bottom cover, you snap the cartridge into place, making sure that any excess tape is fed through the two guides.
Label Making and Printing
The LW-400 supports printing in 14 fonts and 10 type styles, and has more than 300 built-in symbols and over 75 frames. Creating labels is at once straightforward and tricky, as it takes time to get used to the function keys?many of them similar looking?and I found myself constantly referring to the instructions at first.
One function key toggles between upper and lower case; one sets type size (you can have either one or two lines of text on the label); one lets you choose the font and another, the type style (bold, italic, outline, etc.). One function key lets you add punctuation; another, symbols; and yet another, accents. A Setup button performs various functions, among them specifying label length; adjusting space between characters; chaning the font width, creating vertical text, and creating mirror-image text. A preview button scrolls through the text you?ve entered and lets you know label length. A barcode key lets you create specialty label types. Although it takes time to master the different functions, and I had many false starts, everything I tried eventually seemed to work as billed.?
The LW-400 took 11.7 seconds to print a 2.6-inch-long label reading This is a test and 19.2 seconds for a 4.8-inch label reading PCMag: Printer Speed Test, essentially the same speed as the Epson LW-300. The Brother P-touch PT-2730 took 11.6 seconds to print a 3.5-inch-long label, also reading PCMag: Printer Speed Test, while the Dymo LabelManager 420p ($110 street, 4 stars), printed the same text in just 6.5 seconds.? Both the Brother and Dymo match the LW-400?s ?-inch maximum label width.
For the $10 extra you pay for it, the Epson LabelWorks LW-400 offers advantages over the Epson LW-300, including a backlit display, greater label width and the ability to print barcodes and other specialty labels, plus the ability to store more (50) labels in memory. If you need any of these extra features, it?s the clear choice. For about twice the price, the Editors? Choice Brother P-touch PT-2730 and the Dymo LabelManager 420p let you print either standalone or from the relative comfort of a computer keyboard.
More printer reviews:
??? Epson LabelWorks LW-400 Label Printer ??? Epson LabelWorks LW-300 Label Printer ??? HP LaserJet Pro 400 color Printer M451dw ??? Canon Pixma MX512 Wireless Office All-in-One ??? Panasonic KX-MB1520 ?? more
CNBC's Maria Bartiromo discusses the day's top business and financial stories. The market was down today, due to renewed worries about a global slowdown. And new home construction numbers come out tomorrow.
Related Links:
Business & financial news headlines from msnbc.com
PPC management refers to pay per click management. This is a way where newer or present business? concepts may be dispersed on the website. Currently, with the development of technology in all domains of labor, there?s a growth in the numbers of business enterprises. Using the world wide web, trying to find data, social media, business opportunities, marriage, study, and going shopping are all far easier than they ever have been. The net has not just made our world easier though furthermore has supplied a chance to organizations, small or big, all across the globe, to nurture.
The net offers its users numerous alternative ways to promote their company. PPC management has become one of those options. As said before, PPC management is short for pay per click management. An individual who would like to promote their organization ought to develop a commercial that describes the business and compensate some cash to the PPC management site that they?ve chosen to publish their commercial. This commercial will likely be submitted as a sponsored advertisement or a plainly marked one. When anyone clicks on this commercial after it has been published online, the PPC management web site will receive some dough and more people will be informed about the client?s business.
Today, increasing numbers of people are becoming business developers and self-employed. They want to be their own employer as an alternative to working for another person. PPC management is one such method that helps people with a strong will and conviction to showcase their businesses. By opting for PPC management websites, the customer is productive in endorsing their notion to a larger target market.
When looking for a PPC management website to assist your company, you have to be sure to investigate ahead of time. One can find a number of web-sites on the internet that provide PPC management. The one with the top status and has been advised by several people might be the PPC management website you need to decide to use. The advantage of opting for a superb PPC management site is that they direct you to make the ideal advertisement and publish these commercials at the proper areas at the right time. This shows that if in particular, an individual is looking for designer jewelery on-line and the client?s commercial is additionally on designer jewelry, then the PPC management would submit this commercial on the web page where it is going to be quite distinctly visible to the individual looking for designer wristwatches.
The cost of inserting these ads on the internet depends on the measurements and reputation of the key phrases engaged and the proportions of the advertisement in its entirety. If the keyword is a trendy one, then the PPC management organization will most likely ask for more. Furthermore, if the keyword isn?t that common, the expense of placing the commercial on the web will likely be significantly less. Also if the search term is rather long in length, the cost increases and lowers the smaller the keyword. Well known key words focus on those keyword phrases that are very searched on the web.
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Tags: internet marketing, optimize ppc, orange county seo, pay per click, ppc, PPC management, search engine marketing, seo
NEW YORK (Reuters) - Dan Magder recently gave up a top job with private equity firm Lone Star Funds to strike out on his own and become a landlord.
He's joining a growing list of big and small investors who see fat profits to be made in renting out foreclosed homes, especially now the U.S. government is moving ahead with a trial project to sell big pools of single-family homes that Fannie Mae currently owns in some of the hardest-hit housing markets.
Investors seeking higher yields are drawn to foreclosures because the rental market is red hot. But the heated competition for foreclosed homes is reminiscent of the frothy expectations that seem to accompany each new Wall Street investing craze.
Even proponents of buying foreclosed homes are advising caution about the kind of returns that investors can expect to reap and the potential negative headlines that can come with being a landlord.
Critics, meanwhile, contend the federal government is fostering a transfer of wealth of sorts by selling big pools of foreclosed homes to big fund investors and high-net-worth individuals. There's also concern that some of the players who helped create the housing crisis will now benefit by buying foreclosed homes at a steep discount.
Between them, Fannie and Freddie Mac own more than 200,000 foreclosed homes. The nation's banks own more than 600,000 single-family homes, according to RealtyTrac, a housing tracking service.
Housing experts expect the foreclosure machinery to crank up again now that regulators and banks have agreed to a $25 billion settlement to deal with earlier foreclosure abuses.
Some of the high-profile institutional investors who are committing money to buying foreclosed homes - or seriously considering jumping in - include private equity firm TPG Capital, investment firm Oaktree Capital Management, Warren Buffett's Berkshire Hathaway Inc., Starwood Capital, Och-Ziff Capital Management and bond fund manager TCW, say people familiar with the fast-growing market.
PILOT PROJECT
The Federal Housing Finance Agency, which regulates Fannie and Freddie Mac, expects it will receive a considerable number of bids in April for the initial round of 2,500 Fannie-owned homes in cities like Atlanta, Chicago, Los Angeles and Phoenix.
"This is really a test and we don't know what the results will be," says Meg Burns, senior associate director for housing and regulatory policy for the FHFA. "But the beauty of this pilot is we are going out with properties that are largely rented already, so people know what the cash flows look like and we know?it is far preferable to have people living in the homes rather than the properties sitting vacant."
In August, when the FHFA first announced its intention to conduct bulk sales for Fannie and Freddie properties, it received expressions of interest from more than 4,000 investor groups, not-for-profits and other organizations.
If the pilot is successful, the FHFA is also considering selling off pools of distressed mortgages held by Fannie and Freddie, according to people familiar with discussions about that.
On the Internet, the gold rush mentality clearly has taken hold with some small investment firms. Wong Diversified International Investments of Austin, Texas, for example, offers a fund to invest in foreclosed homes, boasting on its website that it is pursuing the Fannie bulk sale.
"It is clearly over-hyped, but I think this is real and it's going to happen," said Magder, who about a week ago left Lone Star, where he had focused on distressed banks and financial services firms. "There is definitely room for people who have a well-thought-out operational plan and are careful about putting the pieces together."
Magder has formed Rock Creek Capital Group, based in Washington, D.C., and intends to raise money from investors and submit a bid for some of the foreclosed homes Fannie is selling in Los Angeles and Phoenix and across Florida.
RETURN ON INVESTMENT
One of the most bullish investors is Carrington Capital Management, which has teamed up with Los Angeles-based OakTree Capital. They have created a $450 million fund to buy foreclosed homes in bulk and rent them out.
In a marketing document for one of its funds, Carrington claims that without using leverage or borrowed money it can generate an annual yield of 7 percent from rental income alone. Its long-term strategy is to package the fund into a publicly traded real estate investment trust. If that strategy is successful, Carrington projects investors can see an internal rate of return of 25 percent over three years.
Rick Sharga, an executive vice president with Carrington, says the firm is optimistic that if the Fannie auction attracts a lot of bidders, then banks will begin holding their own bulk sales of foreclosed homes.
Other investors looking at the foreclosed home market say Carrington's projections seem too rosy and they are projecting a return on investment of between 8 percent and 15 percent. That said, in an environment where U.S. Treasuries are yielding less than 2.5 percent on a 10-year Treasury note, those kind of returns are piquing the interest of wealthy individuals.
Miami-based Carlos Guajardo, who is considering bidding for some of the Fannie properties being sold in bulk in Florida, says he is seeking to raise about $50 million, largely from wealthy individuals and small family offices. To date, his firm Maynada Capital Advisors has acquired about 70 foreclosed homes in southeast Florida, which he has fixed up and is in the process of renting out.
In Las Vegas, Laus Abdo is doing something similar and he's trying to expand his potential reach by partnering with a hedge fund or private equity firm to back him.
"I think the majority of your return in this portfolio comes in the form of cash flow from renting, not capital appreciation, unless you buy properties at a huge discount," says Abdo, executive director at TriArchic Advisors, a Las Vegas-based real estate advisory and management firm.
Even as some investors are getting into the market, others are looking at getting out because they fear the presence of big institutional players will drive up prices.
New York hedge fund manager Jason Ader says he and a business partner in Phoenix are looking at selling some of the more than 100 homes they acquired at foreclosure auctions over the past year. Ader, founder of Ader Investment Management, said the market in Phoenix for foreclosed homes began getting more competitive this year. He expects institutional money will start to crowd out smaller investors bidding for the Fannie properties.
PR NIGHTMARE
Some hedge fund managers say they're staying out of the market largely for fear of getting vilified as being a bad landlord if the need comes to evict a tenant. One manager who did not want to be identified said while there's a lot of money to be made from investing in foreclosed homes, "it is a potential PR nightmare."
In February, Phil Angelides, the former chairman of a federal commission set up to look into the causes of the financial crisis, stepped down as executive chairman of Mortgage Resolution Partners one month after Reuters reported on his involvement in the company which aimed to turn a profit from buying distressed mortgages. Angelides' involvement had drawn scrutiny on Capitol Hill, where one congressman sent a letter warning about potential political influence peddling.
Already, some liberal economists are questioning the wisdom of the federal government pushing to sell homes owned by Fannie and Freddie to institutional investors at a potential 20-30 percent discount to prevailing market price.
"This is actually moving the underlying physical assets, or homes, to the top 1 percent," says L. Randall Wray, a professor of economics at the University of Missouri-Kansas City and a senior scholar with Bard College's Levy Economics Institute.
Laus, the Las Vegas housing entrepreneur, says there could be a "potential backlash" if some of the buyers are subsidiaries of the big banks that got bailed out by the federal government.
But many more public policy experts say the bulk sales by the government are worth trying, given the huge stockpile of foreclosed homes controlled by Fannie and Freddie.
"We have a shortage of rental housing already and I think this is a win-win situation," says Kenneth Rosen, chairman of Rosen Consulting Group, which advises on urban planning and real estate management.
In February, Rosen co-authored a report with mortgage-backed securities guru Lewis Ranieri, which advocated the need for a private sector solution to the foreclosure crisis. A Ranieri-backed hedge fund, Selene Finance, has been investing in distressed mortgages for the past few years and is now eyeing foreclosed homes.
"I don't think the money to do this is the problem," says Rosen. "It's the execution."
(Reporting By Matthew Goldstein and Jennifer Ablan; Editing by Claudia Parsons)
Zug, Switzerland and San Diego, CA Cytori Therapeutics (NASDAQ: CYTX) announced today the publication of RESTORE-2 trial results in the peer-reviewed European Journal of Surgical Oncology.
RESTORE-2 is a 71 patient multi-center, prospective clinical trial using autologous adipose-derived regenerative cell (ADRC)-enriched fat grafting for reconstruction of the breast after cancer surgery. The majority of patients underwent radiation prior to the procedure, creating an unfavorable ischemic environment for which breast reconstruction with ADRC-enriched fat grafting appears to be ideally suited.
Key findings of the trial were:
High rates of investigator (85%) and patient (75%) satisfaction with the overall treatment results at 12 months;
High rates of investigator (87%) and patient (67%) satisfaction with overall breast deformity (based on functional and cosmetic outcomes) at 12 months;
Improved breast contour at both six and 12 months, demonstrated by blinded MRI assessment; and
No local cancer recurrences or serious adverse events related to the ADRC-enriched fat grafting procedure.
"Following cancer treatment, the patient's breast tissue can suffer from radiation injury, scarring and tight skin," said Consultant Plastic and Reconstructive Surgeon Mrs. Eva Weiler-Mithoff, co-principal investigator for RESTORE-2 at the NHS Glasgow Royal Infirmary Hospital. "This new technique is exciting because it may offer the opportunity to resolve some of the most difficult to treat conditions where other approaches, including fat alone, do not achieve satisfactory results."
ADRC-enriched partial mastectomy breast reconstruction is marketed in the EU as the RESTORE Procedure and represents an innovative treatment option with significant cost savings potential. The procedure can be performed on an outpatient basis. Satisfactory results can be achieved in a single procedure for the majority of patients. In contrast, competitive approaches are more costly with lengthy hospital stays, require repeat procedures and increase the overall burden on the healthcare system. Furthermore, because of these limitations, physicians are often reluctant to recommend reconstruction for patients with partial mastectomy defects and radiation-induced damage in the breast.
Each year, approximately 450,000 European women are diagnosed with breast cancer. Of the newly diagnosed breast cancer cases, 70-80% are eligible for breast conserving surgery, where only a portion of the breast is removed rather than the full breast. In the European G5, there are an estimated 1.25 million women who have undergone partial mastectomy. The majority of these patients are left with a sizeable volume defect, scarring and often radiation damage.
"Given that there is no widely accepted reconstructive option available today for partial mastectomy patients, this procedure could well address this substantial unmet need and help complete the overall cancer treatment," said Marc H. Hedrick, president of Cytori.
###
The European Journal of Surgical Oncology is the official journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
About the RESTORE Procedure
During the RESTORE Procedure, fat is taken from the patient's stomach, hips, thighs, or other areas by liposuction. Some of the tissue is processed in Cytori's Celution system to extract the patient's own regenerative cells which occur naturally inside the tissue. The extracted cells are then combined with the remaining fat tissue, forming an ADRC-enriched fat graft that is injected into the breast to restore its natural look and feel. In addition to providing an entirely natural reconstruction, the procedure is minimally invasive with the potential to reduce scarring. The Celution system is not commercially available in the United States.
About the RESTORE-2 Trial
RESTORE-2 is a 71 patient European post-marketing trial primarily intended to measure patient and physician satisfaction in reconstructing the breast utilizing the Celution system. The trial took place at the following sites: Hospital General Universitario Gregorio Maran in Madrid, Spain, Glasgow Royal Infirmary in Glasgow, Scotland, KU Leuven University Hospitals in Leuven, Belgium, Azienda Ospedaliero Universitaria Careggi in Florence, Italy, Instituto Valenciano Oncologa in Valencia, Spain, Norfolk and Norwich University Hospital in Norwich, England, and Jules Bordet Institute of Cancer in Brussels, Belgium.
About Cytori
Cytori Therapeutics is developing cell therapies based on autologous adipose-derived regenerative cells (ADRCs) to treat cardiovascular disease and repair soft tissue defects. Our scientific data suggest ADRCs improve blood flow. As a result, we believe these cells can be applied across multiple ischemic conditions. These therapies are made available to the physician and patient at the point-of-care by Cytori's proprietary technologies and products, including the Celution system product family. www.cytori.com
This press release includes forward-looking statements regarding events, trends and business prospects, which could affect our future operating results and financial position, such as our expectation of increased hospital and patient availability, and our expectation of acceptance of the treatment for lumpectomy and radiation scarring. Such statements are subject to risks and uncertainties that could cause our actual results and financial position to differ materially. Some of these risks and uncertainties include regulatory uncertainties, the perceived quality of our clinical data, physician and patient acceptance of our technology, and other risks and uncertainties described under the "Risk Factors" in Cytori's Securities and Exchange Commission Filings, including its annual report on Form 10-K for the year ended December 31, 2011. Cytori assumes no responsibility to update or revise any forward-looking statements contained in this press release to reflect events, trends or circumstances after the date of this press release.
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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Zug, Switzerland and San Diego, CA Cytori Therapeutics (NASDAQ: CYTX) announced today the publication of RESTORE-2 trial results in the peer-reviewed European Journal of Surgical Oncology.
RESTORE-2 is a 71 patient multi-center, prospective clinical trial using autologous adipose-derived regenerative cell (ADRC)-enriched fat grafting for reconstruction of the breast after cancer surgery. The majority of patients underwent radiation prior to the procedure, creating an unfavorable ischemic environment for which breast reconstruction with ADRC-enriched fat grafting appears to be ideally suited.
Key findings of the trial were:
High rates of investigator (85%) and patient (75%) satisfaction with the overall treatment results at 12 months;
High rates of investigator (87%) and patient (67%) satisfaction with overall breast deformity (based on functional and cosmetic outcomes) at 12 months;
Improved breast contour at both six and 12 months, demonstrated by blinded MRI assessment; and
No local cancer recurrences or serious adverse events related to the ADRC-enriched fat grafting procedure.
"Following cancer treatment, the patient's breast tissue can suffer from radiation injury, scarring and tight skin," said Consultant Plastic and Reconstructive Surgeon Mrs. Eva Weiler-Mithoff, co-principal investigator for RESTORE-2 at the NHS Glasgow Royal Infirmary Hospital. "This new technique is exciting because it may offer the opportunity to resolve some of the most difficult to treat conditions where other approaches, including fat alone, do not achieve satisfactory results."
ADRC-enriched partial mastectomy breast reconstruction is marketed in the EU as the RESTORE Procedure and represents an innovative treatment option with significant cost savings potential. The procedure can be performed on an outpatient basis. Satisfactory results can be achieved in a single procedure for the majority of patients. In contrast, competitive approaches are more costly with lengthy hospital stays, require repeat procedures and increase the overall burden on the healthcare system. Furthermore, because of these limitations, physicians are often reluctant to recommend reconstruction for patients with partial mastectomy defects and radiation-induced damage in the breast.
Each year, approximately 450,000 European women are diagnosed with breast cancer. Of the newly diagnosed breast cancer cases, 70-80% are eligible for breast conserving surgery, where only a portion of the breast is removed rather than the full breast. In the European G5, there are an estimated 1.25 million women who have undergone partial mastectomy. The majority of these patients are left with a sizeable volume defect, scarring and often radiation damage.
"Given that there is no widely accepted reconstructive option available today for partial mastectomy patients, this procedure could well address this substantial unmet need and help complete the overall cancer treatment," said Marc H. Hedrick, president of Cytori.
###
The European Journal of Surgical Oncology is the official journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
About the RESTORE Procedure
During the RESTORE Procedure, fat is taken from the patient's stomach, hips, thighs, or other areas by liposuction. Some of the tissue is processed in Cytori's Celution system to extract the patient's own regenerative cells which occur naturally inside the tissue. The extracted cells are then combined with the remaining fat tissue, forming an ADRC-enriched fat graft that is injected into the breast to restore its natural look and feel. In addition to providing an entirely natural reconstruction, the procedure is minimally invasive with the potential to reduce scarring. The Celution system is not commercially available in the United States.
About the RESTORE-2 Trial
RESTORE-2 is a 71 patient European post-marketing trial primarily intended to measure patient and physician satisfaction in reconstructing the breast utilizing the Celution system. The trial took place at the following sites: Hospital General Universitario Gregorio Maran in Madrid, Spain, Glasgow Royal Infirmary in Glasgow, Scotland, KU Leuven University Hospitals in Leuven, Belgium, Azienda Ospedaliero Universitaria Careggi in Florence, Italy, Instituto Valenciano Oncologa in Valencia, Spain, Norfolk and Norwich University Hospital in Norwich, England, and Jules Bordet Institute of Cancer in Brussels, Belgium.
About Cytori
Cytori Therapeutics is developing cell therapies based on autologous adipose-derived regenerative cells (ADRCs) to treat cardiovascular disease and repair soft tissue defects. Our scientific data suggest ADRCs improve blood flow. As a result, we believe these cells can be applied across multiple ischemic conditions. These therapies are made available to the physician and patient at the point-of-care by Cytori's proprietary technologies and products, including the Celution system product family. www.cytori.com
This press release includes forward-looking statements regarding events, trends and business prospects, which could affect our future operating results and financial position, such as our expectation of increased hospital and patient availability, and our expectation of acceptance of the treatment for lumpectomy and radiation scarring. Such statements are subject to risks and uncertainties that could cause our actual results and financial position to differ materially. Some of these risks and uncertainties include regulatory uncertainties, the perceived quality of our clinical data, physician and patient acceptance of our technology, and other risks and uncertainties described under the "Risk Factors" in Cytori's Securities and Exchange Commission Filings, including its annual report on Form 10-K for the year ended December 31, 2011. Cytori assumes no responsibility to update or revise any forward-looking statements contained in this press release to reflect events, trends or circumstances after the date of this press release.
[ | E-mail | Share ]
?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
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WASHINGTON (AP) ? Afghanistan's ambassador to the United States says his country is committed to a long-term partnership with the U.S., but the road ahead may be full of bumps.
The diplomat, Eklil Hakimi, says his government is an ally in the fight against terrorism and wants to make sure that terrorists cannot again use Afghanistan as a base to threaten the security of other countries.
But a series of incidents has severely strained ties with the U.S.
One was from the inadvertent burning of Qurans by U.S. soldiers. More recently, the war effort was driven to a new low by the killing of nine Afghan children and seven adults, allegedly by a U.S. soldier.
The ambassador tells CNN's "State of the Union" that Afghanistan is working to define its relationship with the U.S. for the years to come, and that's the big picture. But he acknowledges that "down the road, it's a bumpy road."
As for making sure the alleged shooter is brought to justice, Hakimi says "we trust the United States and we know how important this relationship is."
The wonderland called eCommerce. Today, some countries are bustling doing many of their offering online while others are starting to hearing with their online market. In presumably box eCommerce is here to stay. This letter won?t broadcast any light on a destiny of eCommerce. No! Rather, we will be confusing my best to collect in-depth information in method to assistance we know how eCommerce has evolved. The debate has been some-more than customarily majestic.
1960
EDI (Electronic Data Interchange) permits companies to lift out electronic transactions. Although a visualisation of eCommerce did not reason a daily Internet user cell a date of 1990s nonetheless some vast players had started to use EDI as early as 1960. The tyrannise courtesy was among a initial to know a stress of EDI and start controlling a same. Other players in a ride courtesy followed.
1979
There is always a hero. Someone who comes out of nowhere and does something unusual. eCommerce has a possess hero. Michael Aldrich is a man. It was a year 1979 when Aldrich was on a ramble in a supermarket with his wife. Suddenly, he was strike by an suspicion that altered it all for eCommerce. Aldrich connected a domestic TV and a resource with write lines so as to start offering groceries online around this model. How they were means to tackle several situations is a conflicting story altogether, nonetheless during a finish of a day they did come adult with a denote that helped them launch a business of online shopping.
1981
Have a feeling during this rare PDF and thereafter examination along. It was a year 1981 when Thomson Holidays picked adult 66 ride agents from around England and connected them in method to come adult with what has been tagged as initial B2B (Business to Business) online shopping. These agents were means to mislay information online and know what was permitted from a Thomson Brochure so as to offer business instantly.
1982
This was a year for France to jot down her name in a story books. France shaped telecom organisation invented Minitel that has been counsel as a many duty pre-WWW online service. Even during a kid years users had a boon to make online purchases, check phone directories, plead with any other and several other elementary searches customarily like it happens in today?s Internet.
[via Wikipedia]
1984
How would it sound if someone tagged we as a initial ever home shopper on this planet. Well, Jane Snowball was tagged as a initial ever home shopper when during a age of 72 she became Tesco?s customer. It was a year 1984 itself when a world?s initial B2C (Business-to-Consumer) online offering element was launched by Tesco. The online offering element started a visualisation of Online Shopping Basket that was after renamed Online Shopping Trolley.
Also, it was Apr 1984 when CompuServe announced Electronic Mall that was roughly like a eCommerce of today.
1987
Next adult was a Merchant Account launched in a year 1987 that helped module developers sell their module products online. SWREG was a name and it happens to be one of a oldest pieces of module that is still available.
1990
Here we go. The year that remarkable a launch of a initial web browser. The name of a browser was WorldWideWeb that was after renamed to Nexus so as to prevaricate a apparent confusion. Nexus was also a editor for programmers who coded websites. During those days Nexus was pretended to be a customarily center to opening a Internet in graphical format. The laughable prejudiced is that a browser was launched for a open by controlling Internet newsgroups as a center of communication. This will assistance we know that a communication element (on a Internet) of those days wasn?t as vast as it is nowadays.
1991
Back thereafter NSFNET was a restraint of a Internet, nonetheless it wasn?t permitted for content use. It was a year 1991 when a NSF (National Science Foundation) absolved a proceed for a content use of NET. This was counsel to be a critical boost for a eCommerce courtesy and a destiny growth. Statistics state that a trade on a restraint network of NSF jumped to over 1 trillion bytes per month in a year 1991 itself after it was uninterrupted for content use. By 1996 there were over 10 million hosts online and a Internet was now a tellurian phenomenon.
It was a year 1991 itself when University of Minnesota launched ?gopher?, a initial point-and-click shaped browser that could be used to navigate files on a Internet. At times this has been tagged as a birth of Internet. Gopher was creatively designed to moderate campus communication.
?The initial Internet concentration my mom can use.? ~ Mark MaCahil, Team Lead of a resource programming organisation that launched Gopher.
1992
A book called ?Future Shop: How new technologies will change a proceed we mart and what we buy? was published in a year 1992. The book was counsel dissident concern a fact that it talked about what will start in a destiny of eCommerce and how a Internet will take shape.
?Snider and Ziporyn (the authors of a book) heartily news a refreshment highways of a future, that will not customarily advantage consumers nonetheless will also produce romantic opportunities for schools, hospitals, businesses, and a normal American as we enter a Information Age of a 21st century.? ? Conrad Burns, Chair of U.S. Senate Communications Subcommittee
1994
This could be tagged as a ?Mother of all Years? for eCommerce as Netscape launched encryption certificate that became a certain means of transmitting information over a Internet. Certificates gave a browsers a probability to trust a source before displaying a information and empathize personal information. Something that helped a finish consumer immersion some-more charisma on a Internet and indirectly on eCommerce transactions.
This wasn?t all. The year 1994 also remarkable a launch of Yahoo! nonetheless a domain was thoroughbred after in a year 1995. This truly gave a Internet and eCommerce a totally new direction.
1995
It was a year 1995 when NSF started charging a cost for initiation domain names. we wish we was inherited before so that we could have thoroughbred some of a prerogative unaccompanied word dot com domains in 1995! At that time a Internet had 12,000 domain names thoroughbred and a array jumped to over 2 Million in a successive 3 years.
January 18, 1995 was a day when a domain Yahoo.com was registered. The word Yahoo is an acronym for ?Yet Another Hierarchical Officious Oracle.?
One strait know that by now a lot of other services that would after sequence a web had started to appear. Some of these were Amazon, AuctionWeb (which after became eBay) and Verisign etc.
1998
PayPal came into existence in a year 1998. The tide PayPal element that we see is indeed a partnership of X.COM, a financial use organisation of a late 2000s, and Cofinity that happened to be a arrangement and cartographic company. It was a year 1998 customarily when Google entered a star of eCommerce and Yahoo! launched Yahoo! Stores online.
2000 and Onwards
As they say, what followed after Google is history. Be it a dot com gurgle or a Web 2.0, a Internet has means exponential enlargement (with a possess pitfalls) that has done a lives of many. As we know it, a Internet continues to grow with critical and teen eCommerce companies rising their possess set of stores. Today, we can literally buy anything around a Internet. That is a wonderland of eCommerce.
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Public release date: 19-Mar-2012
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